Facial oiliness and wrinkles, scalp dandruff and hair loss—these issues have long plagued countless consumers.
Continuing its legacy of focused innovation, French company EXSYMOL has recently launched ADESILNAT, a 100% natural-origin ingredient. By utilizing their proprietary Silanol Technology, EXSYMOL has successfully combined active silicon with adenosine. This single ingredient delivers comprehensive care for both the “face and head”—simultaneously controlling oil, preventing hair loss, and diminishing wrinkles.
1.1 Breakthrough Ingredient Technology: 1+1>2 Synergy
EXSYMOL is the pioneer of Silanol technology, having introduced the first Silanol series in 1974. Over the past 51 years, EXSYMOL has consistently launched new Silanol raw materials while continuously iterating its technology.
This year, Silanol Technology has undergone a major upgrade—achieving 100% natural origin status. The new product, ADESILNAT, is created by combining bio-active silicon derived from rice husks with adenosine derived from fermentation, utilizing proprietary Silanol technology.
- Adenosine: Naturally present in the human body, it is a key component of DNA/RNA and participates in energy metabolism. In skin care, it offers anti-wrinkle, firming, and skin barrier repair benefits. When applied to the scalp, it helps prevent hair loss, densify hair, and prolong the hair follicle growth phase.
- Silicon: Known as the “Natural Architect,” silicon is abundant in human connective tissue. However, levels drop by 58% after the age of 40. Silicon is essential for rebuilding the extracellular matrix (ECM), providing strength and flexibility to both skin and hair strands.
Through Silanol technology, EXSYMOL transforms difficult-to-absorb silicon into a highly bioavailable Silanol aqueous solution. This creates a powerful synergistic effect with the fermented adenosine:
Scientific Validation: Experiments show that 0.25% ADESILNAT achieves a 13% proliferation rate in Hair Follicle Dermal Papilla Cells (HFDPC). This performance far exceeds the results of using active silicon alone (5%) or adenosine alone (which showed no significant effect), truly realizing a 1+1>2 efficacy upgrade.
2.1 Scalp Care: Balancing Sebum & Reducing Dandruff
Note: Adenosine is naturally present in the human body, a key component of DNA/RNA, and participates in energy metabolism. In skin care, it provides anti-wrinkle, firming, and barrier repair effects; on the scalp, it strengthens hair, prevents loss, and extends the follicle growth phase.
Clinical Study Results (In Vivo):
In a 28-day test involving 40 volunteers aged 25–45:
- Sebum secretion: Reduced by 11%
- Dandruff improvement rate: Reached 50%
- Scalp hydration: Increased by 12%
2.2 Scalp Care: Anti-Hair Loss, Strengthening & Densifying
Factors such as aging, pollution, and stress cause hair follicles to degenerate, forcing hair into the telogen (resting) phase prematurely.
Mechanism of Action:
ADESILNAT promotes the proliferation of Hair Follicle Dermal Papilla Cells (HFDPC) and stimulates the production of key growth factors:
- Keratinocyte Growth Factor (KGF): +38%
- Vascular Endothelial Growth Factor (VEGF): +33%
It also activates hair follicle stem cell expression mechanisms (Marker K15 increased by 152%), promoting hair regeneration capabilities and extending the anagen (growth) phase.
Benchmark Efficacy:
Notably, the hair growth promotion effect of ADESILNAT is comparable to Minoxidil.
84-Day Clinical Trial Results:
In a study involving 15 women suffering from telogen effluvium (stress/shock hair loss):
- Hair Retention: Saved approximately 5,800 hairs from falling out.
- Hair Density: Increased by 19%.
- Pull Test: Hair loss reduced by 56.3%.
- 60-Second Combing Test: Hair loss reduced by 47.5%.
- Hair Thickness: Significantly improved.
- Cellular Health: Activates autophagy to clear damaged organelles, delaying scalp aging.
3.1 Facial Care: Dual Action for Oil Control & Anti-Aging
ADESILNAT is perfectly adapted for oily skin and skin showing early signs of aging (“Pre-Aging”), delivering a “Oil Control + Anti-Aging” dual approach.
Oil Control Efficacy:
- Shine Reduction: 12% elimination of oily shine after 28 days.
- Pore Care: Inhibits excessive keratinocyte proliferation caused by inflammation, reducing pore blockage to target acne at the source, leaving skin with a fresh, matte finish.
Anti-Aging Efficacy:
- Stimulates the synthesis of Collagen and Hyaluronic Acid.
- 28-Day Results: Wrinkle depth reduced by 9%, skin thickness increased by 5%, and dermal density improved by 6%.
- Mechanism: Silanol reverses fibroblast senescence and optimizes the collagen network; Adenosine enhances skin elasticity and fades wrinkles, restoring a healthy, translucent glow.
4.1 Natural Origin + Versatile Application: The Safe Choice
ADESILNAT adheres to strict natural and eco-friendly standards:
- Active Silicon: Upcycled from rice husks.
- Adenosine & 1,3-Propanediol: Derived from fermentation.
- Free from: Palm oil.
- Certification: 100% Natural Origin (ISO 16128).
- Safety: Safe, gentle, and environmentally friendly.
Product Specifications:
- Appearance: Colorless to pale yellow transparent liquid.
- Scent: Mild/Light odor.
- pH Stability: 2.5 – 4.5.
- Solubility: Soluble in water and polyols.
- Recommended Dosage: 5%.
- Applications: Ideal for scalp serums, hair masks, or facial care products.
- Status: Strictly clinically verified; Patent pending.
Formulation Flexibility:
It can be paired with ASTRASINOL to enhance anti-inflammatory properties, or with CAPALGIN to synergistically boost anti-hair loss and strengthening effects, adapting to diverse care needs.
Summary
Today’s consumers are no longer satisfied with simple “1+1” active ingredient combinations; they demand synergistic amplification.
France’s EXSYMOL utilizes its original Silanol Technology to use skin-friendly active silicon as a delivery system to potentiate other actives, achieving a true 1+1>2 result.
ADESILNAT, composed of pure natural-origin adenosine and silanol, delivers anti-hair loss and strengthening effects approaching those of 1μM Minoxidil at just 0.5% concentration. With versatile applications for both face and hair, it is a high-tech, high-efficacy ingredient perfectly aligned with the Clean Beauty trend.