Prolonged mask-wearing causing sudden breakouts? Washing your hair only to find your scalp oily and flaky right after? Concerned about harsh preservatives irritating your sensitive skin?
To resolve these common consumer pain points, SEPPIC’s advanced “Purifying Factor”—LIPACIDE™ C8G (INCI: Capryloyl Glycine)—is the ideal formulation solution. It effectively addresses stubborn skin and scalp conditions while functioning as a powerful safeguard for your cosmetic formulations!
LIPACIDE C8G: The Natural “Purifying Powerhouse”
The core advantage of LIPACIDE C8G lies in its unique molecular structure. Utilizing proprietary AMINOVECTOR™ Technology (Lipo-Amino Acid Technology), a plant-derived caprylic acid derivative is grafted onto Glycine—the most abundant amino acid naturally found in human skin. This creates an amphiphilic structure, ensuring unparalleled skin affinity and biocompatibility.
- Formulation Friendly: It presents as a stable, colorless-to-white powder that is easy to process, does not impact the final product’s appearance, and remains highly effective across varying pH environments.
- Safety & Compliance: LIPACIDE C8G is inherently preservative-free and acts as a powerful preservative booster, allowing for a reduction of traditional preservatives in the formula. It is fully compliant with China’s IECIC 2015, listed as a Japan Quasi-Drug (QD) Additive, holds RSPO Mass Balance sustainability certification, and boasts a Natural Origin Content (NOC) of over 50%.
Targeted Blemish Control: Combat “Maskne” in 14 Days with Sebum Regulation & Barrier Repair
“Maskne” (mask-induced acne) has become a widespread skin concern. Surveys indicate that 43% of people experience skin blemishes from wearing masks, and 72% are actively bothered by it. LIPACIDE C8G delivers targeted, clinically proven results to combat this issue.
In Vivo Clinical Efficacy:
In a clinical trial, 22 volunteers with oily, acne-prone skin who wore masks for 2–5 hours daily applied a lotion containing 1% LIPACIDE C8G twice a day:
- Day 14: Inflammatory lesions (papules, pustules) were reduced by 44%, and non-inflammatory lesions (blackheads, microcysts) were reduced by 61%.
- Day 28: Total blemishes decreased by a maximum of 74%. Additionally, pore appearance scores improved by 31%, and skin roughness decreased by 46%, resulting in a visibly refined and smoother skin texture.
Skin Barrier Repair:
LIPACIDE C8G is also an expert at restoring the acid mantle. After disrupting the skin barrier with an alkaline buffer, applying a 1.5% LIPACIDE C8G solution restored the skin’s healthy, acidic pH level within just 15 minutes, rapidly rebuilding its defense against external irritants.
In Vitro Efficacy & Sebum Control:
- Antibacterial Action: Proven to inhibit acne-causing bacteria, including Staphylococcus aureus and Cutibacterium acnes (C. acnes), addressing oily and blemish-prone skin at its root.
- 5α-Reductase Inhibition: In vitro fibroblast tests reveal that just 0.1% LIPACIDE C8G inhibits 5α-reductase activity by 50%. This outperforms the positive control, Finasteride (30ng/mL), which only showed a 35% inhibition rate. By targeting excess sebum production at the source, it significantly improves skin oiliness and unwanted shine.
Scalp Purification: Improve Dandruff and Oily Scalp in 1 Month While Soothing Irritation
For recurring dandruff, greasy scalp, and redness often linked to seborrheic dermatitis, LIPACIDE C8G delivers outstanding therapeutic-grade results.
Clinical Trial Data (University of Milan, School of Pharmacy):
In a study involving 40 volunteers suffering from seborrheic dermatitis, participants used a shampoo formulated with 2% LIPACIDE C8G once every three days.
After 1 Month: Dandruff transformed from “dense and heavy” to “minimal or completely eliminated.” Scalp sebum levels improved from “extremely oily” to “slightly oily.” Symptoms of irritation, such as redness and itching, were significantly soothed.
Targeting the Root Cause of Dandruff:
LIPACIDE C8G effectively inhibits Malassezia, the primary fungus responsible for recurring dandruff. In vitro testing demonstrates a highly effective Minimum Inhibitory Concentration (MIC) of just 0.75% against Malassezia in a pH 5 environment, stopping dandruff generation at the source.
Formulating for Sensitive Skin: Reducing the Preservative Burden
Consumers with sensitive skin are increasingly cautious about traditional preservatives in skincare. LIPACIDE C8G acts as a “Formula Guardian.”
Its broad-spectrum antimicrobial properties effectively cover Gram-positive and Gram-negative bacteria, yeasts, and molds. A small addition acts as a powerful antimicrobial booster. Furthermore, it works synergistically with standard preservatives like Phenoxyethanol and Parabens, allowing formulators to significantly lower their required concentrations—resulting in a gentler, more sensitive-skin-friendly product.
Patented Synergy: Advanced Antibacterial Cleansing Gel
Leveraging the potent antimicrobial power of LIPACIDE C8G, it can be synergistically combined with zinc-based surfactants and salicylic acid to create a patented antibacterial complex. When applied to cleansing formulations, this combination does more than just wash the skin—it actively inhibits bacterial growth, regulates the skin’s pH, and thoroughly protects the skin’s natural chemical barrier.
Summary: Ideal Applications for LIPACIDE C8G
- Oily / Acne-Prone & “Maskne” Skin: Delivers rapid blemish reduction, active sebum regulation, and pore refinement, resolving recurring acne directly at the source.
- Advanced Scalp Care: Eliminates stubborn dandruff, controls excessive scalp oil, and soothes scalp sensitivity, maintaining long-lasting freshness.
- Sensitive Skin Formulations: The perfect ingredient for low-preservative or preservative-free product concepts, ensuring mild, non-irritating care.
From comprehensive facial care to targeted scalp treatments, and from aggressive oil control to formula protection, LIPACIDE C8G proves its status as the ultimate “Purifying Star” backed by robust clinical data!

