Mastering both scalp and skin care—why did this breakthrough ingredient win the prestigious Fountain Award Gold?
Adenosine is a critically important substance in the human body, participating in cellular metabolic activities in multiple forms.
Recognizing its immense potential, the French laboratory Exsymol combined Adenosine with their proprietary “Silanol” technology to create ADESILNAT™, a 100% natural-origin plant-based adenosine silanol. Delivering comprehensive benefits—from sebum control and hair loss prevention to wrinkle reduction—this multifunctional ingredient offers complete “face-to-scalp” care.
Thanks to its exceptional performance, this innovative active won the Gold Fountain Award in the “Hair & Scalp Care” category at this year’s PCHi (Personal Care and Homecare Ingredients) exhibition.
In this article, we take an in-depth look at the science, clinical data, and formulation benefits of ADESILNAT.
1. The 1+1>2 Synergistic Effect
Laboratory studies demonstrate that ADESILNAT at a concentration of 0.25% promotes the proliferation of Human Follicle Dermal Papilla Cells (HFDPC) by 13%. This significantly outperforms the isolated use of active silicon (5%) or adenosine (which showed no significant effect on its own), achieving a true 1+1>2 synergistic efficacy upgrade.
2. Advanced Scalp Care
2.1 Balancing Sebum Secretion and Reducing Dandruff
The scalp is the “soil” for healthy hair. ADESILNAT directly targets the root causes of hair loss and dandruff.
- In Vitro Efficacy (Oil Control): Tests show that a 0.3% concentration reduces sebum production by 22%. A 0.25% dose inhibits keratinocyte hyperproliferation caused by Malassezia-induced inflammation by 25%.
- In Vivo Efficacy: In a 28-day clinical trial with 40 volunteers (aged 25-45), participants experienced an 11% reduction in sebum secretion, a 50% improvement in dandruff, and a 12% increase in scalp hydration.
2.2 Anti-Hair Loss, Strengthening, and Volumizing
Factors like aging, pollution, and stress cause hair follicles to degenerate, forcing hair prematurely into the telogen (resting) phase.
ADESILNAT promotes HFDPC proliferation and stimulates the production of vital growth factors, including Keratinocyte Growth Factor (KGF, +38%) and Vascular Endothelial Growth Factor (VEGF, +33%). It also activates the expression mechanism of hair follicle stem cells (Stem cell marker K15 increased by 152%), effectively prolonging the anagen (growth) phase of the hair cycle.
Remarkably, ADESILNAT’s efficacy in promoting hair follicle growth is clinically comparable to that of Minoxidil!
2.3 Activating Cellular Autophagy for High Regenerative Potential
Furthermore, ADESILNAT actively triggers cellular autophagy. This biological process clears damaged organelles and effectively “detoxifies” the cells—a mechanism crucial for normal and healthy hair follicle growth.
2.4 Clinical Testing Data
In a rigorous 84-day clinical trial involving 15 women suffering from telogen effluvium (stress-induced hair loss), the use of ADESILNAT yielded extraordinary results:
- Total hair loss reduced by approximately 5,800 hairs.
- Overall hair density increased by 19%.
- Hair loss during the pull test decreased by 56.3%.
- Hair loss from 60 seconds of combing decreased by 47.5%.
- Hair thickness and volume visibly improved.
3. Facial Care: Dual Action for Oil Control & Anti-Aging
ADESILNAT is highly adaptable for oily and early-aging skin, successfully achieving a dual “Oil Control + Anti-Aging” effect.
- Oil Control: After 28 days of use, the oil-shine elimination rate reached 12%. By inhibiting keratinocyte hyperproliferation triggered by inflammation, it reduces pore blockages, addresses acne at its root, and leaves the skin with a fresh, matte finish.
- Anti-Aging: It actively stimulates the synthesis of collagen and hyaluronic acid. Within 28 days, wrinkle depth was reduced by 9%, skin thickness increased by 5%, and dermal density improved by 6%. The silanol core reverses fibroblast senescence and optimizes the collagen network, while adenosine enhances skin elasticity and fades wrinkles, restoring a healthy, translucent glow to the skin.
4. 100% Natural Origin + Versatile Application = A Safe & Reliable Choice
ADESILNAT adheres to strict eco-friendly and natural formulation philosophies:
- The active silicon is upcycled from rice husks.
- The adenosine and 1,3-propanediol are derived from bio-fermentation.
- It is palm-oil-free and boasts a 100% Natural Origin Index (ISO 16128), making it safe, mild, and environmentally sustainable.
Formulation Guidelines:
Backed by rigorous clinical validation (patent pending), ADESILNAT is a clear to slightly milky liquid with a mild odor.
- pH Range: 2.5 – 4.5.
- Solubility: Soluble in water and polyols.
- Recommended Dosage: 5%.
- Applications: Ideal for scalp serums, hair masks, and premium facial care formulations.
Synergies:
For customized formulation needs, ADESILNAT can be paired with ASTRASINOL to boost anti-inflammatory properties, or synergized with CAPALGIN to further elevate its anti-hair loss and root-strengthening efficacy.
Conclusion
In today’s cosmetic innovation landscape, which increasingly prioritizes “depth of mechanism” and “breadth of efficacy,” ADESILNAT stands out. Its core competitiveness lies not only in the 1+1>2 synergistic effect enabled by Exsymol’s silanol technology, but also in its powerful cellular autophagy activation mechanism. By clearing metabolic waste and repairing damaged organelles for both hair follicles and skin cells, it reboots the body’s high regenerative potential from the root.
Built on a 100% natural origin foundation, backed by Minoxidil-comparable anti-hair loss power, and supported by quantifiable clinical data, ADESILNAT is the ultimate solution for unparalleled “dual care for face and hair.”